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Megan Sherbenou’s scientific interests center around human biology, evolution and health. She teaches classes that address these topics (e.g., Human Anatomy and Physiology). The primary focus of her research is the effect of high altitude hypoxia (low oxygen) on humans; this includes both the short- and long-term effects of hypoxia and how the human body adjusts to compensate. Sherbenou has studied genetic, biochemical, anatomical and physiological differences among populations (modern human evolution) and between healthy and non-healthy individuals.

Sherbenou has also conducted field work at high altitude locales, such as Leadville, Telluride, and Bolivia.